Based on the genetic and epigenetic profiles, 3 distinct molecular subgroups-AT/RT-TYR, AT/RT-SHH, and AT/RT-MYC have been recently identified and the prognosis of ATRT seems to differ by 3 molecular subgroups (2, 5, 6).The ATRT-TYR subgroup is enriched in genes associated with melanogenesis and neural crest development, such as TYR and DCT, and is often linked to older children with relatively better prognosis (7). Here, TYR is linked to atypical teratoid rhabdoid tumor.