Gentles et al. (2015) identified KLRB1 (CD161) as a favorable prognostic gene through an investigation of expression profiles across 18,000 human tumors encompassing 39 malignancies. Another study (Pan et al., 2020) demonstrated that KLRB1 was a potential pivotal gene linked to a more favorable prognosis in HCC. This evidence concerns the gene KLRB1 and hepatocellular carcinoma.