Markunas and colleagues (Markunas et al., 2014) showed that DNA methylation is changed in 110 gene regions and notably FRMD4A, a gene associated with Alzheimer disease (AD) and nicotine dependence and CNTNAP2, a gene associates with neural development, autism spectrum disorder, schizophrenia, and language impairment. This evidence concerns the gene FRMD4A and Alzheimer disease.