Considering the results of our recent research, which showed that UDCA and CDCA reduce the expression of NF-κB in the liver and the level of pro-inflammatory cytokines in the endotoxemia (Milivojac et al., 2024), NF-κB could be the main target of the beneficial effect of these bile acids on the expression of AQP1 and AQP5 in endotoxin-induced ALI. This evidence concerns the gene AQP5 and acute respiratory distress syndrome.