By activating target genes associated with antioxidant response elements (ARE), like heme oxygenase‐1(HO‐1) and NAD(P)H: quinone oxidoreductase 1 (NQO1), Nrf2 inhibits the progression of EMT and alleviates the pathological state of PF (Wang et al. 2022c). Here, NQO1 is linked to pemphigus foliaceus.