In this study, the BLM‐induced group had higher levels of pro‐inflammatory cytokines (IL‐1β, IL‐6, and TNF‐α) and lower levels of the anti‐inflammatory cytokine (IL‐10) compared with the control group, and these BLM‐induced changes were attenuated by RRFBs. This evidence concerns the gene IL1B and Bloom syndrome.