COPB1 was shown to be essential for Influenza A Virus (IAV) infection in siRNA-based study (Haas et al., 2023) and it was also required for the infection of RNA viruses including vesicular stomatitis virus and SARS-CoV-2, for facilitating essential steps in viral RNA synthesis and trafficking or viral assembly (Knoops et al., 2010; Panda et al., 2011). Here, COPB1 is linked to infection.