PTEN and steatosis: Histological analysis of liver sections in the fed state (Fig. 1B), together with intrahepatic triglyceride (TG) content (Fig. 1C), revealed that the severe steatosis present in PTENKO mice was greatly reduced in the absence of IR (PTEN-IRKO mice) in the fed state; however, deletion of both receptors appears to have cumulative effects on steatosis clearance, as observed in the triple-KO group.