SMARCB1 and neoplasm: TfRscFv enables the efficient delivery of a plasmid containing the human wild-type SMARCB1 gene to tumor cells.The scL-SMARCB1 nanocomplex restores SMARCB1 expression, which in turn inhibits the proliferation of ATRT (atypical teratoid/rhabdoid tumor) cells and induces senescence and apoptosis.