Depletion or selective inhibition of EZH2 leads to compensatory upregulation of EZH1 expression, whereas depletion of EZH1 enhances the effect of EZH2 inhibition.Preclinical studies have found that dual inhibitors of EZH1/2 significantly suppress the growth of MRT (Malignant Rhabdoid Tumor) cells, specifically manifested by a reduction in the accumulation of H3K27me3 at the CDKN2A locus, which is one of the targets of EZH1/2. The gene discussed is EZH1; the disease is rhabdoid tumor.