SMARCB1 and cancer: Studies have shown that SMARCB1 is a tumor suppressor gene in vivo, and SMARCB1 deficiency is observed in human malignant tumors such as T cell lymphoma rare rhabdoid tumors (40); SMARCB1 is involved in chromatin remodeling and transcriptional regulation, and is closely related to the processes of cell differentiation and cell proliferation (40).