However, after subgroup analysis, IL-10 1082A>G was found to be significantly associated with the risk of NPC in Asian populations(Allele model: OR=2.10, 95% CI = 1.64-2.69, p<0.00001, I2 = 0%, Figure 3A, Dominant model: OR=2.19, 95% CI = 1.64-2.92, p<0.00001, I2 = 0%, Figure 3B, Recessive model: OR=2.95, 95% CI = 1.50-5.77, p=0.002, I2 = 0%, Figure 3C, Heterozygote model OR=2.02, 95% CI = 1.49-2.75, p<0.00001, I2 = 0%, Figure 3D, Homozygote model OR=3.51, 95% CI = 1.78-6.90, p=0.0003, I2 = 0%, Figure 3E). This evidence concerns the gene IL10 and nasopharyngeal carcinoma.