• Neuroblastoma cell lines, especially MYCN-expanded cell lines, are sensitive to this inhibitor. The inhibitor has a significant inhibitory effect on the growth activity of tumor cells, induces apoptosis and mediates G1 phase block.• Combination with vincristine enhances vincristine-mediated growth inhibition when used in p53-mutant neuroblastoma cell lines. The gene discussed is TP53; the disease is neuroblastoma.