This immune activation leads to endothelial dysfunction through multiple convergent pathways: direct cytokine‐mediated endothelial activation (increased ICAM‐1, VCAM‐1, E‐selectin expression), anti‐tTG antibody cross‐reactivity with cerebral endothelium, and systemic inflammatory effects [18]. The gene discussed is TGM2; the disease is endothelial dysfunction.