CRIM1 and coloboma: Heterozygous deletions predicted to result in haploinsufficiency for CRIM1 have been identified in families with eye defects comprising colobomatous macrophthalmia with an increased axial length of the globe, microcornea, and coloboma of the iris, chorioretinal structures, and optic disc (Toker et al., 2003; Beleggia et al., 2015; Haug et al., 2021).