Conditional knock-out mice with a Clic4-null allele in the retinal pigment epithelium (RPE∆Clic4 mice) develop the clinical, histological, and functional hallmarks of dry age-related macular degeneration (Chuang et al., 2022), and complement is also known to play an important role in the pathogenesis of age-related macular degeneration (Fritsche et al., 2010). The gene discussed is CLIC4; the disease is age-related macular degeneration.