In gastric cancer (GC) tissues, NSUN2 is significantly upregulated compared to adjacent normal tissues, with its expression positively correlated to factors such as tumor differentiation, lymph node metastasis, elevated Ki67 levels, and peritoneal metastasis (Table 1) (Fang et al., 2023; Hu et al., 2021; Liu et al., 2023; Mei et al., 2020; Shen et al., 2024) Higher NSUN2 expression is associated with reduced overall survival (OS) in patients with GC, and univariate analysis identifies it as an independent prognostic risk factor for OS (Fang et al., 2023; Hu et al., 2021; Liu et al., 2023). The gene discussed is NSUN2; the disease is neoplasm.