Furthermore, NSUN2 inhibition reduces the phosphorylation of ERK1/2, leading to decreased levels of the anti-apoptotic protein Bcl-2 and increased levels of the pro-apoptotic protein Bax (Figure 2), thereby sensitizing GC cells to 5-FU/CDDP by enhancing apoptosis (Shen et al., 2024). The gene discussed is NSUN2; the disease is gastric cancer.