NSUN6 plays a critical role in CRC and PDAC; in CRC, higher NSUN6 expression is linked to advanced tumor stages and lower survival rates, while in PDAC, reduced NSUN6 expression negatively correlates with prognostic markers like T stage and Ki67 positivity (Cui et al., 2024; Yang R. et al., 2021). The gene discussed is NSUN6; the disease is colorectal carcinoma.