Studies have revealed abnormal expression patterns of m5C methyltransferases, including NSUN2 and NSUN6, as well as m5C-binding proteins like YBX1 and ALYREF, in cancers such as esophageal, gastric, hepatocellular, colorectal, and pancreatic cancers. The gene discussed is NSUN6; the disease is familial pancreatic carcinoma.