Specifically, NSUN2 expression is positively correlated with tumor size, TNM stage, and overall tumor stage, while NSUN6 expression is closely associated with ethnicity and tumor stage (Table 1) (Chen B. et al., 2024; Cui et al., 2024; Zou et al., 2024) Patients with CRC exhibiting elevated NSUN2 expression have poorer OS and disease-free survival (DFS) rates compared to those with lower NSUN2 levels (Chen B. et al., 2024; Zou et al., 2024). This evidence concerns the gene NSUN6 and neoplasm.