- Decrease in total ERK1/2 levels- TG2 and CD44v6 both form complexes with ERK1/2, as well as with themselves (immunoprecipitation assay)- CD44v6 ICD is necessary for CD44v6/TG2 complex formation- Cancer xenografts display a significant decrease in tumor growth compared to the control, accompanied by reduced CD44v6 and ERK1/2 levels. The gene discussed is MAPK3; the disease is neoplasm.