BCL2 and urinary bladder cancer: Further investigations into the role of CD44v3 in apoptosis regulation unveiled that the knockdown of CD44v3-containing isoforms mediates the reduction of PI3K, pAKT, pERK, pSTAT3 and Bcl2 protein levels, triggering apoptotic signaling and G0/G1 phase arrest in bladder cancer cells (Anand et al., 2019).