IL1B and Alzheimer disease: Different literatures revealed that amyloid beta (Aβ) activates the microglia and induces synthesis and release of free radicals, proinflammatory cytokines, and chemokines, such as nitric oxide (NO), tumor necrosis factor alpha (TNF-α), and interleukin 1 beta (IL-1β), which are hallmarks of AD and PD (6, 7).