Notably, we found that the expression of COL22A1 positively correlates with common immune checkpoints such as PD-1 (PDCD1), PD-L1 (CD274), and LAG3 in GBM, suggesting that COL22A1 may play a significant role in regulating immune evasion mechanisms in GBM. The gene discussed is LAG3; the disease is glioblastoma.