However, the most highly differentially expressed transcripts have no established role in neutrophil-mediated bacterial immunity, though some have been described to mediate neutrophil-dependent disease in non-infectious pathologies, such as enoyl-CoA delta isomerase 2 (Eci2) in colorectal cancer and solute carrier family 2 member 9 (Slc2a9) in hyperuricemic neutrophil inhibition (38, 39). This evidence concerns the gene ECI2 and colorectal cancer.