LRRK2 and Parkinson disease: Prior studies have suggested that individuals with LRRK2 parkinsonism may be less likely to demonstrate motor complications compared with sporadic Parkinson’s Disease cases, especially among females.40 However, in those studies biologic characterization was not available.40 Our findings indicate that the more benign phenotype in LRRK2-associated parkinsonism may be driven by asyn-negative cases.