In light of the differences in MDS-UPDRS II in the LRRK2 parkinsonim CSFasynSAA− versus CSFasynSAA+ cases, we next examined differences in LRRK2 CSFasynSAA− versus sPD CSFasynSAA+, as this analysis can provide insights as to whether the differences are unique to LRRK2 parkinsonism or are rather more a reflection of asyn aggregates status. Here, LRRK2 is linked to Parkinson disease.