LRRK2 and Parkinsonism: A lower prevalence of olfactory deficit among LRRK2-associated parkinsonism has been previously identified,40,51 but in PPMI it has been demonstrated that this finding is largely restricted to LRRK2-associated parkinsonism without evidence of asyn aggregates.4 In a study40 of 530 LRRK2-associated parkinsonism and compared with 759 sporadic Parkinson’s Disease cases, female LRRK2 parkinsonism individuals were less likely to have olfactory deficit.40 However, in that study, biological characterization was not present.