Women have a greater burden of neurofibrillary tangles,41,42 and women with Alzheimer’s disease pathology are more likely to manifest clinically with dementia but not to be diagnosed with dementia with Lewy bodies (DLB).42 The effect of sex on tau may even be brain region specific, and females may have network characteristics favouring spread of tau.43 Women with Alzheimer’s disease pathology are more likely to have copathology with TDP/hippocampal sclerosis and cerebrovascular disease. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.