In the few available studies that compared clinical features in LRRK2-associated cases according to asyn status, a few clinical differences have been described.2 Kalia et al.2 demonstrated that among cases of LRRK2-associated parkinsonism, some non-motor symptoms associated with typical sporadic Parkinson’s disease such as anxiety, orthostasis and cognitive changes are more likely in those with evidence of asyn aggregates.2 This evidence concerns the gene LRRK2 and Parkinsonism.