Indeed, some neuropathologically examined cases with confirmed Lewy body pathology have been CSF asyn SAA−; these are most often focal Lewy pathology, such as in the amygdala or brainstem.34 On the other hand, there is a reported case of LRRK2-associated parkinsonism that did not demonstrate post-mortem Lewy pathology but demonstrated asyn aggregates on brain homogenate by asyn SAA.35 Regardless of detection of asyn, of course, this does not exclude the possibility that pathogenic variants in LRRK2 may impact asyn function without leading to Lewy pathology or abnormal CSF SAA.36 This evidence concerns the gene LRRK2 and Parkinsonism.