LRRK2 and Parkinson disease: We undertook this study with the objectives of comparing among LRRK2-associated parkinsonism cases with and without evidence of asyn aggregates whether there are (i) differences in clinical features cross-sectionally and longitudinally, (ii) distinguishing features in available biofluid or imaging markers cross-sectionally and longitudinally and (iii) differences in prevalence of Parkinson’s disease genetic risk variants.