Biesenbach et al. [10] conducted a retrospective study that included T1DM and T2DM patients undergoing insulin treatment (MDI) and found that insulin requirements decreased progressively from CKD G1 to G5: T1DM patients dropped from 0.72 U kg−1∙d−1 to 0.45 U kg−1∙d−1, and T2DM patients decreased from 0.68 U kg−1∙d−1 to 0.33 U kg−1∙d−1. This evidence concerns the gene INS and type 2 diabetes mellitus.