Although it has been established that mutations in Pkd1 cause defects in endothelial development (Coxam et al., 2014; Kim et al., 2000; Outeda et al., 2014) and flow-mediated dilation of the systemic vasculature (Hamzaoui et al., 2022), the phenotype of the kidney microvasculature ADPKD is less well understood, particularly from a molecular standpoint. The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.