PKD1 and kidney disorder: The uniqueness of the molecular phenotype of the microvasculature observed in ADPKD compared to kidney diseases, and parallel findings in Pkd1RC/RC mice, could be driven by intrinsic consequences of a PKD1 pathogenic variant or deletion on endothelial development and function (Hamzaoui et al., 2022; Huang et al., 2016; MacKay et al., 2020).