Among the two groups, NTIS patients were more likely to have greater chronic liver failure and malignant tumour history; APACHE II score; SOFA score; CRP; and PCT but had lower absolute lymphocyte counts; CD4+ T cells; CD8+ T cells; and C3, C4, albumin, prealbumin, transferrin, FT3, FT4 and TSH levels. The gene discussed is TTR; the disease is chronic liver failure.