At the time of the cross-sectional study, no significant differences in age at study, disease duration, age at diagnosis, alcohol consumption, prednisolone daily dose, fatigue scores, depressive scores, anxiety score, nor average annual SLEDAI-2 K scores (based on all available visits) were seen in high versus low IFN-α lupus phenotype patients. This evidence concerns the gene IFNA2 and systemic lupus erythematosus.