A hypothesis that aligns with AD literature is to use all three biomarkers ApoE proteotype, plasma A\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}β42/40 ratio, and age together to enroll participants for Alzheimer’s disease drug trials. This evidence concerns the gene APOE and Alzheimer disease.