SEMA7A and acute respiratory distress syndrome: At 24 h post APAP-ALI, during peak Sema7a expression, Sema7a KO mice had the same percentage of TUNEL + nuclei as WT mice, but TUNEL + nuclei were not contained within the centrilobular necrotic areas and there were TUNEL + cells in the surrounding healthy parenchyma (Fig. 7, p = 0.0151), suggesting Sema7a plays a localised role to limit the extent of liver tissue damage at 24 h post APAP-ALI.