While the percentage of subjects with LGS progressively increased from the NLDLR group to the LDLR null group, (p for trend < 0.05), the prevalence of patients with HGS decreased from the NLDLR group to the LDLR null group (p for trend < 0.05; Fig. 3A). This evidence concerns the gene LDLR and Lennox-Gastaut syndrome.