Analysis of the frequency distribution of XRCC1 (Fig. 2d) and γH2AX (Fig. 2e) intensities in all nuclei measured, demonstrated a γH2AX selective, decrease in the frequency of peak intensities and a rightward extension of the intensity profile for both NeuN + and NeuN- nuclei in DLB cases compared to controls. This evidence concerns the gene XRCC1 and Lewy body dementia.