For all cases, where available (n = 13 for controls and n = 11 for DLB cases), TMA slides containing temporal cortex tissue punches were stained for hallmark pathology associated with DLB, foremost Lewy neurite and Lewy body pathology, but also Aβ-plaques and AT-8 phospho-tau (Supplementary Fig. 2a). The gene discussed is MAPT; the disease is Lewy body dementia.