While the amount of polynuclear cells, monocytes, CD8 + T-lymphocytes and NK-cells, seems normal, we show in both patients a significantly low rate of B-lymphocytes and CD4 + T-lymphocytes, predominantly in the naive subpopulation (CD4 + CD45RA + ), with a CD4+ count below 500 cells/μL, theoretically compatible with opportunistic infections [20]. The gene discussed is CD4; the disease is Opportunistic infection.