Spatiotemporal single-nuclei analysis of the PCOS-endometrium reveals that 16 weeks of metformin and lifestyle management reverse many dysregulated genes, particularly in epithelial SOX9+LGR5+ and AR+ cells, stromal fibroblasts, SMCs and uNK2 and uM2 subpopulations. The gene discussed is AR; the disease is polycystic ovary syndrome.