ITGB6 and polycystic ovary syndrome: For integrin-mediated signaling and ECM organization, in PCOS-endometrium both treatments restored expression of ArgGluAsp receptors (ITGB6, ITGB8 and ITGAV), collagen receptor ITGA2, laminin receptor ITGA3 and ADAMTS9 (linked to reduced oocyte maturation in PCOS)27,28.