Together these findings suggest that hyperandrogenism and insulin resistance predominantly affect epithelial subclusters (AR+, SOX9+LGR5+, SOX9+LGR5−, SOX9+ cycling) and stromal subclusters (stroma 1, stroma 2, stroma cycling, fibroblasts), contributing to the risk of endometrial dysfunction in women with PCOS. The gene discussed is LGR5; the disease is hyperandrogenism.