For integrin-mediated signaling and ECM organization, in PCOS-endometrium both treatments restored expression of ArgGluAsp receptors (ITGB6, ITGB8 and ITGAV), collagen receptor ITGA2, laminin receptor ITGA3 and ADAMTS9 (linked to reduced oocyte maturation in PCOS)27,28. This evidence concerns the gene ITGB8 and polycystic ovary syndrome.