CLDN5 and polycystic ovary syndrome: In the PCOS-endometrium, the smallest subcluster, endothelial or lymphatic (2,308 nuclei) (Fig. 4g–i), showed downregulation of PDE3A, SULF1, FN1 and CLDN5 in an endothelial artery subcluster and FN1, CD9 and DSCAM in lymphatic cells, with upregulation of HDAC9 in the endothelial artery subcluster (Fig. 4j, Supplementary Table 2a–c and Extended Data Fig. 4g,h).