In PCOS, epithelial subclusters activate COLLAGEN, LAMININ, cell adhesion molecule (CADM) and protein tyrosine phosphatase receptor type M (PTPRM) pathways, whereas stromal subclusters engage PTPR, insulin-like growth factor (IGF), adhesion G protein-coupled receptor L (ADGRL) and SLIT. The gene discussed is IGF1; the disease is polycystic ovary syndrome.