Strikingly, we observed remarkable similarities in the phenotypes derived from expression of catalytically inactive caspase 8 (CASP8 CA) in mammals (Fritsch et al, 2019; Newton et al, 2019) and overexpression of catalytically inactive AtMC1 in plants, both leading to some form of autoimmunity. Here, CASP8 is linked to Autoimmunity.