Both ubiquitous and PC-specific Cacna1a disruption also recapitulated several hallmarks of ataxia: reduced locomotion in an open field (Fig. 6c,d and Extended Data Fig. 9c); impairments in skilled motor behavior, as assessed by narrowing beam crossing (Fig. 6e, Extended Data Fig. 9d and Supplementary Videos 1 and 2); reduced limb strength (Fig. 6f); and gait deficits (Fig. 6g,h and Extended Data Fig. 9e–h). This evidence concerns the gene CACNA1A and cerebellar ataxia.