CACNA1A and Generalized non-motor (absence) seizure: We next assessed whether the specificity afforded by transcriptional crosstalk in the PC-specific paradigm could circumvent the epileptic activity observed with forebrain-specific disruption of Cacna1a. Thus, in a separate cohort of animals, we conducted longitudinal cortical electroencephalography (EEG) recordings, starting 1 week before and continuing 6 weeks after AAV injection (Fig. 6i), monitoring for spike-and-wave discharges (SWDs) that are characteristic of absence seizures.