The sgACC in depression in DLB correlates with α-synuclein pathology in late onset MDD, indicating that α-synuclein may be a factor in MDD development in older individuals [36], intimately involved in the aetiology of depression [10, 27] and a high α-synuclein pathological burden in DLB [28]. Here, SNCA is linked to Lewy body dementia.