ATG7 and neoplasm: In co-cultures of T47DPar CLuc+ with either T47DATG7 FLuc+-GLuc+ (Test-Suspension) or T47DPar FLuc+-GLuc+ cells (Control-Suspension), the ATG7-knockout tumor cells were progressively depleted by DCA and Metformin, confirming their metabolic vulnerability in a competitive setting in vitro (Supplementary Fig. 5b–d).