We concluded that 4E-BP1T37/46 phosphorylation correlates with p62 accumulation in primary HR+/Her2− and triple-negative breast cancer patients and that combined high levels of p4E-BP1T37/46 and p62 are associated with reduced OS in the HR+/Her2− subgroup, thereby serving as prognostic biomarkers. This evidence concerns the gene SQSTM1 and triple-negative breast carcinoma.