SQSTM1 and neoplasm: Compared to breast tumors from untreated mice, which contained both tumor cell types, tumors from the Alpelisib-treated cohort displayed upregulation of mTORC1 signaling, defects in p62 degradation, increased FLuc and GLuc and reduced CLuc level, consistent with the Alpelisib-induced enrichment of T47DAR1 FLuc+-GLuc+ and negative selection of T47DPar CLuc+ cells (Fig. 6b–e).