High HRH1 expression levels were recently reported in different cancers including HCC, colorectal cancer (CRC), breast cancer (BC), melanoma, and non-small cell lung cancer (NSCLC) [13, 35] and were correlated with growth, metastasis, or therapeutic resistance of these cancer types [17, 19, 36–38]. This evidence concerns the gene HRH1 and hepatocellular carcinoma.