Protein signatures of microglia from mice exposed to the HFHS diet revealed an involvement of adipocytokine signaling and highlighted innate activation characteristics, and likewise included a higher abundance of proteins including Ndufs2, Ndufs1 and Mapk1 that are involved in Alzheimer’s disease and which are particularly related to mitochondrial dysfunction. This evidence concerns the gene NDUFS2 and Alzheimer disease.