Other reported non-canonical functions of the anti-apoptotic BCL2 family members include regulation of senescence, inflammation, metabolism, mitochondrial morphology, and calcium homeostasis.331,332 With so many roles of these proteins above and beyond suppression of apoptosis, it is perhaps unsurprising that in a large screen across different cancer types there was a poor correlation between BCL2 family RNA expression and BH3-mimetic sensitivity (Fig. 6). The gene discussed is BCL2; the disease is cancer.