Downregulation of miR-15/16 has been observed in CLL, prostate cancer, pituitary adenomas, and mesothelioma, thus contributing to high BCL2 expression in these malignancies.196–200 In leukemic cells, miR-145 downregulates BCL2 and simultaneously induces BAX expression.201 Additionally, the miRNAs themselves are influenced by lncRNAs that act as molecular sponges and thereby hinder the repressing effect of miRNAs.202. The gene discussed is BCL2; the disease is B-cell chronic lymphocytic leukemia.