BCL2 and colorectal cancer: In preclinical research, A1155463 has been shown to be effective at low nanomolar concentrations against colorectal cancer cells with high expression of BCL-XL, as well as other solid malignancies.359,360 A1331852 similarly has been shown to induce apoptosis across a variety of entities, but as well as A1155463, was used mainly as a tool compound to investigate the importance of singular anti-apoptotic BCL2 family members.