MCL1 and lymphoma: In lymphoma cells, NA1-115-7 stabilized MCL1, disrupted the BAK/MCL1 interaction, and rapidly induced apoptosis in a BAK- and BAX-mediated process.380 Moreover, NA1-115-7 induced tumor cell death while demonstrating no toxicity to cardiomyocytes or normal blood cells.380 Like many other natural compounds, it has a lipophilic structure, and its susceptibility to acidic environments may impede its oral administration and, consequently, its clinical development.