BAX and Parkinson disease: Interestingly, BAX inhibition is able to prevent LMP, restore lysosomal levels and prevent accumulation of undegraded autophagosomes both in vitro and in vivo.477 Besides lysosomal defects, PD is characterized by degeneration of dopaminergic neurons in substantia nigra pars compacta (SNpc) and the loss of nerve fibers in the striatum.