BCL2 and early-onset autosomal dominant Alzheimer disease: The BCL2 family of proteins plays a crucial role in neuronal survival and apoptosis regulation within the central nervous system (CNS) and hence it is not surprising that BCL2 proteins are implicated in numerous neurological diseases including Alzheimer’s disease (AD).447,448 AD is characterized by the accumulation of amyloid plaques consisting of amyloid β (Aβ).