MCL1 and colorectal cancer: In colorectal cancer the c-Myc/miR-1271-5/NOXA/MCL1 axis can be targeted through BET inhibitor treatment in combination with BH3-mimetics to induce apoptosis, highlighting the interplay of many epigenetic mechanisms in one treatment.237 Often, miRNAs also target transcription factors or proteins of signaling pathways, whose dysregulation in turn affects the expression of BCL2 family genes.