BAK1 and Parkinson disease: Increasing evidence supports a role of dysregulated lysosomal function as an early feature in Parkinson disease (PD), and more specifically impaired lysosomal membrane permeabilization (LMP).474 The role of BAX/BAK in LMP and autophagic cell death,475,476 and its functional link to PD-linked lysosomal dysregulation has become clearer in recent years.