BCL2 and Alzheimer disease: These results suggest that inhibition of deranged ryanodine receptor channels in AD likely contributes to the neuroprotective role of BCL2 thereby inhibiting excessive Ca2+ responses in AD.470 However, since the molecular determinants in BCL2 responsible for ryanodine receptor binding remain elusive, BCL2 mutants that are defective in ryanodine receptor binding are not yet available to firmly establish ryanodine receptors as the neuroprotective targets of BCL2.