BCL2 and follicular lymphoma: The founding and eponymous anti-apoptotic protein, BCL2, was discovered in 1984 as the gene involved in the t(14;18)(q32.3;q21.3) chromosomal translocation found in 85% of follicular lymphoma (FL).7–9 This translocation juxtaposes the BCL2 gene on chromosome 18 with the immunoglobulin heavy chain (IGH) enhancer region on chromosome 14, which results in an overexpression of BCL2.