MCL1 and breast carcinoma: This may be explained by its genetic proximity to the tumor suppressor gene Deleted in Colon Cancer (DCC) which lies 11 Mb centromeric of BCL2 on the long arm of chromosome 18.271,272BCL2L1 and MCL1 on the other hand are commonly (about 5% of cases) amplified in solid tumors; BCL2L1 in colorectal cancer, while MCL1 is most commonly amplified in breast cancer.