However, target protein expression has been defined as a poor biomarker of BH3-mimetic sensitivity in multiple cancer models.301,333–335 In a pan-cancer analysis, the gene knockout effects do not resemble the response to venetoclax or navitoclax, and only an association between navitoclax response and a BCL2L1 gene dependency is observed (Fig. 6). Here, BCL2L1 is linked to cancer.