BCL2L1 and neoplasm: It has been reported to interact with GABA Receptor Associated Protein (GABARAP), a molecule involved in autophagosome biogenesis328 and overexpression of BCL2 lacking its BH4 domain commits melanoma cells to autophagy.329 Interactions of the BH4 domains of BCL2 and BCL-XL have also been linked to roles in proliferation, differentiation, DNA repair, cell migration and tumor progression.330 These interactions would not be hindered by BH3-mimetics.