The formation of large tumors with microscopic features of cellular pleomorphism and anaplasia and increased Ki-67 expression in mice injected with KCL22-NTC cells in comparison to Ptbp2-KO-KCL22 xenografts provide convincing evidence that the presence of PTBP2 simultaneously promotes proliferation, leading to aggressive tumor formation. Here, PTBP2 is linked to neoplasm.