Compared with those in the Vector-SCC25 group, tumors in the OE-PER2-SCC25 group had a significantly reduced weight and volume (Fig. 3B); a significantly increased expression of PER2, DLAT, PDHB, and SLC31A1 (Fig. 3C); significantly increased intra-tumor concentrations of copper and DLAT oligomers (Fig. 3D, E); a significantly decreased electron transport chain complex I and II activity (Fig. 3F); significantly increased fumarate and α-ketoglutarate levels (Fig. 3G); and a significantly decreased Ki67 expression (Fig. 3H). This evidence concerns the gene PER2 and neoplasm.