SIRT6 and Other metabolic disease: Txnip, which was authenticated to be important in glucose transport-related glucolipid metabolism [27–29] and important in chronic inflammatory and metabolic diseases-related glycolysis molecular regulation [23, 30, 31], has been demonstrated to driving oxidative stress, inflammation-induced endoplasmic reticulum stress (ERS), and NLRP3 inflammasome activation [32] through such as Sirtuin 6 (SIRT6) activity decline [14], Peroxisome Proliferators Activated Recepotor δ (PPARδ) activation [15] to caused chondrogenesis and ECM deposition obstruction.