SLC30A1 and amyotrophic lateral sclerosis: For this reason, to investigate the role of ZnT1 in ALS, we used SOD1G93A mice, a familial model of ALS, to determine: (i) mRNA and protein expression of ZnT1 in the spinal cord of mice at different disease stages, (ii) microRNAs capable of regulating ZnT1 expression, (iii) whether ZnT1 modulation through microRNAs can improve motor neuron survival, reduce neuroinflammation, and ameliorate motor performance.