MAPT and frontotemporal dementia: Thus, increased tau in postsynaptic compartments may also lead to increased vulnerability to NMDA-mediated excitotoxicity, and in support of this, the expression of FTD mutant tau led to increased trapping of Fyn in dendritic spines through increased tau self-assembly properties (Padmanabhan et al. 2019; Martínez-Mármol et al. 2023).