MAPT and tauopathy: Cryogenic electron microscopy (cryo-EM) structures from postmortem samples have shown that different tauopathies have specific tau fiber structures observed in multiple patients with a given disease (Fitzpatrick et al. 2017; Falcon et al. 2018, 2019; Zhang et al. 2020a; Shi et al. 2021) (Fig. 2; Table 1).