The nucleotide-binding domain leucine-rich repeat (NLR)-containing family pyrin domain containing 3 (NLRP3) inflammasome is elevated in tau-linked FTD patients, and genetic loss of constituents NLRP3 or apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) ameliorates tau pathology occurring downstream from Aβ in model mice (Ising et al. 2019). The gene discussed is NLRP3; the disease is frontotemporal dementia.