We also identified an additional 12 cases involving a copy loss of BRD4 relative to the neighboring NOTCH3 gene (1 breast, 3 ovarian, 2 endometrial, 3 pancreatic adenocarcinoma, 1 pancreatic endocrine, 1 lung squamous, and 1 hepatocellular cancers; Figure S1), although these were not strictly focal (<100 kbp) deletions. Here, BRD4 is linked to hepatocellular carcinoma.