ID3 and urinary bladder cancer: ID3 is a helix‐loop‐helix (HLH) protein that can bind and sequester class I and II bHLH transcription factors in non‐DNA‐binding dimers, thereby negatively regulating gene expression.[35] It has been reported that ID3 is extensively involved in the regulation of the transcriptional activity of CDKIs.[36, 43, 44] Our results verified that LRPPRC‐m6A‐ID3 axis mediated erdafitinib resistance by inhibiting the transcriptional activity of p16 and p21 in bladder cancer.