Given the role of sustained neuroinflammation and NLRP3 inflammasome hyperactivation in various neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS), this study underscores the therapeutic potential of bilirubin and its WNK1 target in these neuroinflammatory disease management.[43, 45, 47] However, the specific roles and regulatory mechanisms of the proposed bilirubin‐WNK1 signaling pathway in different inflammatory diseases require further investigation. This evidence concerns the gene WNK1 and early-onset autosomal dominant Alzheimer disease.