We have previously reported that elevated serum bilirubin levels in patients with stroke directly activate the transient receptor potential melastatin 2 (TRPM2) channel on neuron cell membranes, worsening brain damage.[10] Despite these findings, the precise target proteins through which bilirubin exerts its cellular regulatory functions and contributes to its anti‐inflammatory roles remain unclear. The gene discussed is TRPM2; the disease is stroke disorder.