As we have stated above, our previous research demonstrated that acute ischemic stroke triggers a transient increase in bilirubin levels (>25 μM) in the region surrounding the injury, where bilirubin acts as a volume neurotransmitter to activate TRPM2 channels (EC50 = 1.9 μM), exacerbating Ca2+‐dependent excitotoxicity in the brain. The gene discussed is TRPM2; the disease is ischemic stroke.