Consistent with our results, bilirubin has been shown to mitigate alum‐induced peritonitis by inactivating the NLRP3 inflammasome.[45, 46] WNK1 has been reported to be a negative regulator of the NLRP3 inflammasome in macrophages.[38] Additionally, we found that the phosphorylation levels of critical nodes in the inflammatory signaling pathway, such as IL‐2 and IL‐18, were significantly altered following WNK1 knockdown. This evidence concerns the gene IL2 and peritonitis.