We have previously reported that elevated serum bilirubin levels in patients with stroke directly activate the transient receptor potential melastatin 2 (TRPM2) channel on neuron cell membranes, worsening brain damage.[10] Despite these findings, the precise target proteins through which bilirubin exerts its cellular regulatory functions and contributes to its anti‐inflammatory roles remain unclear. This evidence concerns the gene TRPM2 and Stroke.