Consistent with our results, bilirubin has been shown to mitigate alum‐induced peritonitis by inactivating the NLRP3 inflammasome.[45, 46] WNK1 has been reported to be a negative regulator of the NLRP3 inflammasome in macrophages.[38] Additionally, we found that the phosphorylation levels of critical nodes in the inflammatory signaling pathway, such as IL‐2 and IL‐18, were significantly altered following WNK1 knockdown. Here, NLRP3 is linked to peritonitis.