Given the significant increase in Sema3E levels observed in IPF patients, particularly in the form of the P61‐Sema3E, and considering previous reports indicating that P61‐Sema3E is the active form of Sema3E in cancer cells, our investigation aimed to delineate the functional significance of different forms of Sema3E in the pathogenesis of IPF. This evidence concerns the gene SEMA3E and idiopathic pulmonary fibrosis.