The previous report showed that Furin inhibitors reduce EMT by inhibiting the cleavage of full‐length Sema3E to P61‐Sema3E, which in turn reduces the invasive and migratory capacity of Colorectal cancer.[15] Since P61‐Sema3E is the main active form of pro‐fibrotic, we tested whether Furin inhibitors has an anti‐fibrotic effect. Here, FURIN is linked to colorectal cancer.