They have been implicated in promoting tumor migration, angiogenesis, and epithelial–mesenchymal transition (EMT).[13, 14, 15] Serum levels of Sema3E are markedly elevated in patients with Systemic Sclerosis (SSc) compared with those in control subjects.[16] In studies pertaining to tissue fibrosis, Yagai et al.[17] reported ameliorated liver fibrosis in Sema3E‐knockout mice compared to that in wild‐type mice in a chronic liver injury model, suggesting a potential association between Sema3E and tissue fibrosis. This evidence concerns the gene SEMA3E and systemic sclerosis.