Here, an extended analysis revealed that CDK2AP1, a gene encoding for a subunit of the NuRD complex, is a critical player in OSCC invasion and metastasis, not only because of its role in regulating epithelial-mesenchymal plasticity but also because of its capacity to modulate inflammation and immunosuppression in the tumor microenvironment. Here, CDK2AP1 is linked to neoplasm.