From this perspective, subtle perturbations in the SWI/SNF-NuRD competition, for example, through micro-RNA driven downregulation of the CDK2AP1 gene as recently shown,33 are likely to favor the partial EMT cellular state at the invasive edge of primary oral carcinomas where they directly interact with the TME and trigger a pro-inflammatory state, as shown here. The gene discussed is SMARCA1; the disease is lip and oral cavity carcinoma.