By blocking A2A receptors (usually dysregulatedin aging, AD, and tauopathies),43 it triggersneuronal molecular mechanisms associated with plasticity and restoresmemory performance, also confirmed by experimental studies on amyloidand tau animal models of AD.44 This researchcould reshape our understanding of nutraceuticals’ role inpreventing and supporting well-being and health. This evidence concerns the gene MAPT and Alzheimer disease.