Yet, the manifestation of SAVI hallmarks in STING ki mice were unaffected by knockout of cGAS, IFNAR1, IRF3, and IRF7 (Luksch et al., 2019; Siedel et al., 2020), suggesting that other pathways in the STING signaling cascade are required for SAVI symptoms. Here, IRF3 is linked to STING-associated vasculopathy with onset in infancy.