Laboratory investigations to confirm the diagnosis and evaluate for potential systemic inflammation include [1, 3]: complete blood count with differential (leukocytosis; lymphopenia), erythrocyte sedimentation rate (elevated), C-reactive protein (elevated), plasma globulins (IgG or IgA; elevated), albumin and calcium levels (hypoproteinemia and hypocalcemia), liver enzymes (elevated), urea and creatinine (elevated), and urinalysis (positive for albumin). The gene discussed is ALB; the disease is Increased total leukocyte count.