BRAF and thyroid tumor: Furthermore, in well-encapsulated or well-defined thyroid tumors with PTC-like nuclear changes, BRAF V600E IHC can serve as an efficient diagnostic tool, as the presence of a BRAF p.V600E mutation is a desirable exclusionary criterion for the diagnosis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) [14].