Our observation of tissue samples from PD mice also confirmed that lncRNA A2M-AS1 could improve the morphological structure of neurons in PD animals and upregulate antioxidant molecules such as SOD and GSH in neurons, which is also consistent with previous reports that exosomes are involved in regulating the oxidative stress process in PD (Wang et al. 2022). Here, SOD1 is linked to Parkinson disease.